Category: Endocannabinoids


The physiology and biochemistry of the Paleolithic Diet AHS 13 with markingsDear Reader,

I just gave a talk at the Ancestral Health Symposium on the potential role of transient receptor potential vanilloid 1 in obesity. Here’s the entire video for you to watch! Watch out for the sing a long at the end, though, you might be singing alone at your desk!

Yours,
drd

Perhaps you were once a fine citizen of the US and discovered that tetrahydrocannabinoid, the active ingredient in marijuana, was a great way to make yourself eat! Via the CB1 receptor mediated mechanism, THC caused you to get the munchies.

It turns out that our favorite fruit sugar and 1/2 of table sugar (sucrose), in the form of fructose, can cause you to do the same as well by activating the same CB1/endocannabinoid pathway.

This suggests that fructose consumers will overeat! The ingestion of fructose and the subsequent cascade in the brain to release endocannabinoids would cause the fructose consumer to overeat!

Indeed, I will be commenting on several positive feedback cycles that can result in overeating! All of these pathways center around excess carbohydrate consumption in one form or another.

Dr D

Erlanson-Albertsson, C. and A. Lindqvist (2010). “Fructose affects enzymes involved in the synthesis and degradation of hypothalamic endocannabinoids.” Regul Pept 161(1-3): 87-91.