Category: Anorexigenic Signals

The physiology and biochemistry of the Paleolithic Diet AHS 13 with markingsDear Reader,

I just gave a talk at the Ancestral Health Symposium on the potential role of transient receptor potential vanilloid 1 in obesity. Here’s the entire video for you to watch! Watch out for the sing a long at the end, though, you might be singing alone at your desk!


Neuroregulation of Appetite & Paleo Nutrition 08.06.2011Dear Friends,

I’m fresh from the very first Ancestral Health Symposium at the University of California Los Angeles. Needless to say, an interesting event! Not only did I get psyched on meeting so many interesting people talking about Ancestral Health, I got to make lots of new friends! And finally getting to meet “phone” friends, like Robb Wolf, Mat LaLonde, Elke Nelson, Ben Balzer and of course, the host Aaron Blaisdell was a real treat. For the record, Aaron, pretty terrific job for a first event! I’m only sorry we weren’t able to join our families for Sunday. Next time! Robb, I’ll see you in Lenexa soon.

I gave a poster at the conference about appetite regulation. It’s just the tip of the iceberg for appetite regulation yet pretty darn complicated. Many people stopped by to view it, though, and I am most appreciative of that. Even if it was a bit over their heads, they let me explain it. Some people were amazed at how complicated the whole thing is. Imagine when I said it was just a blip on the screen in terms of the actual communication between the brain and the body!

In the next month I’ll begin the process of explaining each part of the slide!

Neuroregulation of Appetite & Paleo Nutrition 08.06.2011

This video gives you some basics of appetite regulation from two classes taught at the Jewish Community Center for the Smartest Loser Program in Overland Park, KS on 3/15/2011 and 3/16/2011. Enjoy

Insulin resistance is the bane of the excess carbohydrate diet!

When excess carbohydrates are chronically ingested, the insulin receptors in the brain lose their ability to mediate the anorexigenic signal properly! this is the essence of insulin resistance. Thus, your brain does not get a good signal to stop eating!

The result is catastrophic! Because the anorexigenic signal is not encoded properly, you eat more. And if you eat more carbohydrates, well, then you make more insulin which causes a further increase in insulin resistance! Thus the signal to stop eating is lost! Thus you eat more. This cycle is only going to stop when carbohydrate intake is reduced.